Development of SNP microarray for supplementary paternity testing
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چکیده
We have developed a SNP microarray for paternity testing, which contains 10 SNPs and in addition X and Y chromosome-specific markers. SNPs were selected with an emphasis on their high allele frequency in the Finnish population. Coding regions of known genes were excluded. With this setup of SNPs, we have calculated the average exclusion power in paternity testing to be 86.5%. The array was validated by comparison with the results in 120 paternity trios obtained with microsatellite markers (Profilerk and SGM+k kits, Applied Biosystems). We conclude that the SNP microarray provides a feasible method to obtain additional genotype information especially in complex paternity cases. D 2003 Elsevier B.V. All rights reserved.
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تاریخ انتشار 2004